肿瘤微环境在细胞休眠中的作用及机制
The role and mechanism of the tumor microenviroment in dormant cell
肖羽淇 1潘燕 1邵春林1
作者信息
- 1. 复旦大学放射医学研究所,上海 200032
- 折叠
摘要
转移和复发是晚期肿瘤患者死亡的主要原因,是当前肿瘤治疗的瓶颈.近年来研究发现肿瘤休眠在转移和复发中发挥了重要作用.肿瘤休眠后可在机体内潜伏多年,对放化疗表现出耐受性,是肿瘤复发的重要因素,也是具有临床治疗价值的潜在靶点.现阶段肿瘤休眠可分为细胞休眠、血管性休眠与免疫性休眠.其中细胞休眠指细胞处于可逆的细胞周期阻滞状态,细胞分裂减慢或停止.细胞休眠多伴有细胞增殖因子 Ki-67的减少与细胞周期蛋白调节的缺失,可使细胞获得治疗抗性与免疫抗性.本文重点关注肿瘤细胞休眠,探讨肿瘤微环境与休眠细胞间的相互影响,以期为肿瘤临床试验提供新思路.
Abstract
Metastasis and recurrence are the leading causes of death in patients with advanced tumors and the bottleneck of current tumor treatment.Recent studies have found that tumor dormancy plays an important role in metastasis and recurrence.The dormant tumor can be latent in the body for many years,showing tolerance to radiotherapy and chemotherapy,which is not only a key factor for tumor recurrence but also a potential therapeutic target for oncotherapy.Tumor dormancy can be divided into three categories including cell dormancy,vascular dormancy,and immune dormancy.Cell dormancy refers to the reversible state of cell cycle arrest,where cell division slows down or stops.Cell dormancy is often accompanied by a decrease in the proliferation factor Ki-67 and a lack of regulation of cyclin-dependent kinase,which can lead to therapeutic resistance and immune escape in cells.This review focuses on cell dormancy and explores the interaction between tumor microenvironment and dormant cells,to provide new ideas for clinical trials.
关键词
放射医学/肿瘤学/综述/肿瘤细胞休眠/肿瘤微环境Key words
radioactive medicine/oncology/review/tumor cell dormancy/tumor microenvironment引用本文复制引用
基金项目
国家自然科学基金(12235004)
国家自然科学基金(31271235)
国家自然科学基金(12375338)
出版年
2024
NETL
NSTL
万方数据