The role and mechanism of the tumor microenviroment in dormant cell
Metastasis and recurrence are the leading causes of death in patients with advanced tumors and the bottleneck of current tumor treatment.Recent studies have found that tumor dormancy plays an important role in metastasis and recurrence.The dormant tumor can be latent in the body for many years,showing tolerance to radiotherapy and chemotherapy,which is not only a key factor for tumor recurrence but also a potential therapeutic target for oncotherapy.Tumor dormancy can be divided into three categories including cell dormancy,vascular dormancy,and immune dormancy.Cell dormancy refers to the reversible state of cell cycle arrest,where cell division slows down or stops.Cell dormancy is often accompanied by a decrease in the proliferation factor Ki-67 and a lack of regulation of cyclin-dependent kinase,which can lead to therapeutic resistance and immune escape in cells.This review focuses on cell dormancy and explores the interaction between tumor microenvironment and dormant cells,to provide new ideas for clinical trials.
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