首页|纳米酶在抗菌领域的应用研究进展

纳米酶在抗菌领域的应用研究进展

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自19世纪初期，微生物感染每年影响了几百万人，受到全球各地的普遍重视，已成为全球重要的公共卫生问题。抗生素是一种高效的抗菌方法，但是滥用会造成微生物抗性增强，从而降低治疗效果，导致高死亡率，严重威胁国民健康和社会经济发展。面对日益增长的致病菌威胁，除了开发新型抗菌药物策略，材料科学和纳米技术也显示出在生物医学中应对微生物感染的巨大潜力。活性氧物质(ROS)是生物有氧代谢过程中的一类副产物，通常具有很强的氧化性，在细胞信号传导和保持机体稳定性方面起着重要作用。生物体内的高含量ROS会引起氧化应激。而氧化应激又与衰老、糖尿病、心血管疾病、炎症性疾病、癌症等多种疾病有关。纳米酶具有调控ROS的能力，可以高效杀死多种革兰氏阳性和阴性致病菌。此外，纳米酶兼备纳米材料特有的物理化学性质和易调控的类酶催化活性，具有经济、稳定、可控、易大批量生产的优势，可以利用其类酶催化活性发挥抗菌效果。基于此，论述纳米酶的分类以及功能化纳米材料用于抗菌治疗的展望。
Research Progress on the Application of Nanozymes in the Field of Antibacterial
Since the early 19th century,microbial infections have affected millions of people each year and have become a major global public health problem.Antibiotics are a highly effective antimicrobial method,but their widespread abuse will lead to increased microbial resistance,which will reduce the effectiveness of treatment,lead to high mortality,and seriously threaten national health and social and economic development.In addition to developing novel antimicrobial strategies in the face of the growing threat of pathogenic bacteria,materials science and nanotechnology are also showing great potential for tackling microbial infections in biomedicine.Reactive oxygen species(ROS)are a kind of by-product of aerobic metabolism,usually with strong oxidation,and play an important role in cell signaling and maintaining body stability.High levels of ROS in organisms can cause oxidative stress.Oxidative stress in turn is associated with aging,diabetes,cardiovascular disease,inflammatory diseases,cancer and many other diseases.Nanase has the ability to regulate reactive oxygen species(ROS),which can effectively kill a variety of gram-positive and negative pathogens.In addition,nanase has the unique physical and chemical properties of nanomaterials and the catalytic activity of enzymes-like regulation,which has the advantages of economy,stability,controllability and easy mass production,and can use its enzyme-like catalytic activity to play an antibacterial effect.Based on this,the classification of nanoenzymes and the prospects of functionalized nanomaterials for antibacterial therapy are discussed.

nano enzymeperoxide like nano enzymeH2O2ROSfunctionalized nano enzymesynergistic antimicrobial therapy

杨丽、夏雪芬、杨金燕、杨一璐、杨琦

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德宏师范高等专科学校,云南德宏 678400

纳米酶 类过氧化物纳米酶 H2O2 ROS 功能化纳米酶 协同抗菌治疗

云南省科协德宏师范高等专科学校专家工作站项目德宏州创新团队项目德宏州中青年学术和技术带头人项目德宏师范高等专科学校校级项目德宏师专专家服务站项目云南省教育厅科研项目

SX2020-152021RC00112021RC002202101SX2022-152019J1002

2024

中国科技纵横
中国民营科技促进会

中国科技纵横

影响因子：0.102
ISSN：1671-2064
年,卷(期)：2024.(1)
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