Since the early 19th century,microbial infections have affected millions of people each year and have become a major global public health problem.Antibiotics are a highly effective antimicrobial method,but their widespread abuse will lead to increased microbial resistance,which will reduce the effectiveness of treatment,lead to high mortality,and seriously threaten national health and social and economic development.In addition to developing novel antimicrobial strategies in the face of the growing threat of pathogenic bacteria,materials science and nanotechnology are also showing great potential for tackling microbial infections in biomedicine.Reactive oxygen species(ROS)are a kind of by-product of aerobic metabolism,usually with strong oxidation,and play an important role in cell signaling and maintaining body stability.High levels of ROS in organisms can cause oxidative stress.Oxidative stress in turn is associated with aging,diabetes,cardiovascular disease,inflammatory diseases,cancer and many other diseases.Nanase has the ability to regulate reactive oxygen species(ROS),which can effectively kill a variety of gram-positive and negative pathogens.In addition,nanase has the unique physical and chemical properties of nanomaterials and the catalytic activity of enzymes-like regulation,which has the advantages of economy,stability,controllability and easy mass production,and can use its enzyme-like catalytic activity to play an antibacterial effect.Based on this,the classification of nanoenzymes and the prospects of functionalized nanomaterials for antibacterial therapy are discussed.
关键词
纳米酶/类过氧化物纳米酶/H2O2/ROS/功能化纳米酶/协同抗菌治疗
Key words
nano enzyme/peroxide like nano enzyme/H2O2/ROS/functionalized nano enzyme/synergistic antimicrobial therapy
维普
万方数据