In the daily production of pharmaceutical factories,facilities and equipment such as fluid equipment pipes,decanting pools in sewage treatment stations,sterilization tanks and underground inspection Wells are all involved in confined space operations.The operation into the restricted space has a greater risk of operation,because the restricted space is small,the air is not circulating,flammable and explosive gas and other harmful factors,so it is easy to occur in the personnel into the restricted space operation safety accidents,seriously endanger the life safety of the personnel in the restricted space,pharmaceutical companies also attach great importance to the safety of production.In order to ensure that the pharmaceutical factory in the daily production,repair,maintenance activities to ensure the occurrence of zero accidents in production safety,according to the dangerous characteristics of operation in confined space,this paper from the safety production technical requirements and safety management measures of the corresponding countermeasures,in order to guide the pharmaceutical factory to carry out daily safety work.