With the economic and social development today,there are more and more complex multi-storey buildings in China.The structural system of this type of buildings is huge,and the force is complex,coupled with people's use needs in many aspects.In order to achieve the goal of structural security,we must innovate the structural design mode.Multi-layer concrete frame structure is commonly used in large buildings,with flexible plane layout and superior structural performance.In order to highlight its structural advantages,designers need to optimize the structural details and adjust the key parameters based on the structural characteristics and stress situation of the building.Based on this,this paper focuses on the design points of multi-layer concrete frame structure in order to provide reference for practical work.