To predict the structure and function of human FoxO3 protein with bioinformatics.Bioinformatic tools were used to predict physical and chemical properties.Human FoxO3 contained 673 amino acid residues.The theoretical isoelectric point was 4.98,the calculated molecular mass was 71.3kD,and it was highly conservative in mammal.The signal peptide and transmembrane regions were not found in human FoxO3.The main compositions of protein secondary structure were alpha.helix.beta.extended strand and random coil.which contained one FORK_HEAD domain.The proteins interaction with human FoxO3 were SIRT1、AKT1.Conclusion:Human FoxO3 protein is a hydrophile protein without signal peptide and transmembrane regions and involves in the activation of FoxO signal pathway may play an important role in oxidative stress and tumor progress.Our research can provide useful information for the further study of human FoxO3.
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