首页|Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release

Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release

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In this study,sodium alginate(SA),a non-toxic natural polysaccharide with good biocompatibility and biodegradability,was developed for targeted delivery of curcumin(CUR)in tumor therapy.The strategy is to sulfhydrylate the folic acid(FA)modified SA,and the CUR dissolved in ethyl acetate(EAC)phase is coated in microcapsules by a quick,efficient and environment-friendly sonochemical method.The EAC in the microcapsule core is volatile,which can be recycled and reused to reduce cost.The prepared mi-crocapsules(FA-RSMCs@CUR)exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro.FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro.It is expected to become a low-cost tumor targeting vector in the future,and has the potential to be promoted in clinical application.

Reductive-responsiveSodium alginateMicrocapsuleTargeted deliverySonochemical

Qingye Meng、Shuangling Zhong、Jingfei Wang、Zhenqian Zhang、Yan Gao、Xuejun Cui

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College of Chemistry,Jilin University,Changchun,130012,China

College of Resources and Environment,Jilin Agricultural University,Changchun,130118,China

State Key Laboratory of Supramolecular Structure and Materials,Jilin University,Changchun,130012,China

Weihai Institute for Bionics-Jilin University,Weihai,264400,China

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Pharmaceutical Health Industry Development Special Project of the Science and Technology Department of Jilin Province,ChinaInterdisciplinary Research Funding Program for Doctoral Students of Jilin University

20210401172YY101832020DJX026

2024

10.1016/j.partic.2023.06.006

颗粒学报(英文版)
中国颗粒学会　中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD
影响因子：0.632
ISSN：1674-2001
年,卷(期)：2024.84(1)
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