首页|Preparation of baicalin colon-targeted granules and its intervention effect on ulcerative colitis in rats

Preparation of baicalin colon-targeted granules and its intervention effect on ulcerative colitis in rats

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Baicalin(BA)is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi with excellent antioxidant and anti-inflammatory biological activities.In this study,Eudragit S100 was used as the colonic target material to prepare BA colonic targeting granules(EBCGs)based on plasticizer dry powder coating technology to improve the targeting transportation performance of BA.In vitro studies showed that EBCGs with pH-sensitive properties were successfully prepared by plasticizer dry powder coating,and in vivo animal imaging studies showed that EBCGs could deliver BA to the colon and inhibit the release of BA in the upper gastrointestinal tract(GIT).In vivo studies showed that EBCGs had good therapeutic effects in colitis,which reduced expression levels of tumor necrosis factor alpha(TNF-α)and interleukin-1β(IL-1β)and increased superoxide dismutase(SOD)activities in the colonic tissues of rats with colitis.In conclusion,Eudragit S100 could be used for the preparation of multi-unit oral colon-targeted formulations by plasticizer dry powder coating technology,and our prepared EBCGs had good colon-targeting properties,which could improve the therapeutic effect and provide a potential application for ulcerative colitis(UC).

Plasticizer dry powder coatingColon-targeted granulesIn vivo imagingUlcerative colitis

Yongqing Huang、Yuxin Zhou、Yao Shen、Jin Wang、Liangliang Zhou、Zhenhua Chen

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Jiangxi Provincial Key Laboratory of Drug Design and Evaluation,School of Pharmacy,Jiangxi Science and Technology Normal University,Nanchang,330013,China

Outstanding Youth Foundation of Jiangxi ProvinceNatural Science Foundation of Jiangxi ProvinceNatural Science Foundation of Jiangxi ProvinceDoctoral startup fund of Jiangxi Science and Technology Normal UniversityDepartment Education Science and Technology Research Project of JiangxiOpen Project of Jiangxi Provincial Key Laboratory of Drug Design and Evaluation

20224ACB21601920202BABL20615120202BABL2160262019BSQD015GJJ201134JKD-KF-2104

2024

10.1016/j.partic.2023.03.017

颗粒学报(英文版)
中国颗粒学会　中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD
影响因子：0.632
ISSN：1674-2001
年,卷(期)：2024.85(2)
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