首页|Precise phase adjustment and antibacterial property of copper sulfide particles in confined mesoporous silica nanoreactor

Precise phase adjustment and antibacterial property of copper sulfide particles in confined mesoporous silica nanoreactor

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Bacteria-caused wound infection greatly threatens human health,thus developing an efficient and safe antibacterial agent without drug resistance is still a great challenge.Herein,a confined vulcanization strategy is proposed to construct copper sulfides-loaded dual-mesoporous silica nanospheres(Cux-Sy@DMSNs)with various crystal phases for reactive oxygen species(ROS)-mediated and photothermal antibacterial application.With the pore confinement of DMSNs,the crystal phases of copper sulfides including CuS,Cu9S5 and Cui.96S can be easily controlled by changing the vulcanization temperature.The relationships between the crystal phases and photothermal properties as well as peroxidase-like activity of copper sulfides were systematically investigated.Results show that the obtained CuS@DMSNs exhibited higher photothermal ability with remarkable photothermal conversion efficiency of 36.86％in the second near-infrared region(NIR-II)and better peroxidase-like activity,compared to those of Cu9S5@DMSNs and Cu1.96S@DMSNs.As a result,the in vitro experiments showed the good antibacterial effect against both gram-negative E.coli and gram-positive S.aureus under 1064 nm laser irradiation and the presence of H2O2.Besides,the CCK-8 assay indicated that CuS@p-DMSNs have minimal cytotoxicity against normal human umbilical vein endothelial cells at the ranged concentrations.Therefore,the resultant CuS@p-DMSNs could act as a promising antibacterial agent for deep wound bacterial infection treatment.

Copper sulfidesMesoporous silicaPhotothermalReactive oxygen speciesAntibacterial agent

Shiyu Xu、Jinyong Wu、Zhongzhen Ren、Dechao Niu

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Low Dimensional Materials Chemistry Laboratory,Key Laboratory for Ultrafine Materials of Ministry of Education,Frontier Science Center of the Materials Biology and Dynamic Chemistry,Shanghai Engineering Research Center of Hierarchical Nanomaterials,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai,200237,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of ShanghaiProgram of Shanghai Academic/Technology Research LeaderFundamental Research Funds for the Central Universities111 project

520721245197211220ZR141490022XD1421100B14018

2024

10.1016/j.partic.2023.04.001

颗粒学报(英文版)
中国颗粒学会　中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD
影响因子：0.632
ISSN：1674-2001
年,卷(期)：2024.85(2)
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