首页|pH-sensitive KHA/CMC-Fe3+@CS hydrogel loading and the drug release properties of riboflavin

pH-sensitive KHA/CMC-Fe3+@CS hydrogel loading and the drug release properties of riboflavin

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To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe3+)@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustained-release study using the drop ball method.The tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe3+formed a three-dimensional network struc-ture,where CS was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal stability.The stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe3+)@CS hydrogel spheres were investigated.The results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.

Potassium humateHydrogel spherespH-sensitiveDrug sustained-releaseDrug release model

Jie Song、Xi Li、Yuhua Niu、Lijun Chen、Zhiqiang Wei、Yidan Li、Youqian Wang

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Shaanxi University of Science & Technology,Xi'an,710021,China

National Natural Science Foundation of ChinaShaanxi Province Key R&D ProgramXi'an City Innovation Capability Strong Foundation Plan-Agricultural Technology R&DShaanxi Province Education Department Service Local Special Program ProjectShaanxi Province Key R&D ProgramIndustry-University-Research Cooperation Project of Yulin Science and Technology BureauNational Key R&D Projects in 2021

518031142022NY-19521NYYF002522JC0152020SF-411CXY-2020-0862021YFC1808900

2024

10.1016/j.partic.2023.04.003

颗粒学报(英文版)
中国颗粒学会　中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD
影响因子：0.632
ISSN：1674-2001
年,卷(期)：2024.86(3)
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