首页|Boosted sustained-release with iron-based MOF-derived mesoporous-carbon-spheres as a nitroimidazole drugs carrier
Boosted sustained-release with iron-based MOF-derived mesoporous-carbon-spheres as a nitroimidazole drugs carrier
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Metal-organic framework(MOF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood diseases.In this article,we propose a novel approach to constructing amorphous carbon microspheres(ACMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward ACMs.Effects of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MSPC were investigated in depth.And the loading capacities and sustained-release performances of nitroimidazole drugs over MSPC through simulation internal environment of human body at different pH values was systematically evaluated.The nitro-imidazole drugs loading rate and release time of MSPC are 10％and 17 h under preferred process.Furthermore,the MSPC exhibited very low toxicity on Hela cells and 293T cells at the concentrations tested(10-800 μg mL-1).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrier for nitroimidazole drug delivery.
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