首页|Incense smoke(IS)inhalation exposure system:Physicochemical characterization,IS particle deposition and clearance in human airway using MPPD model

Incense smoke(IS)inhalation exposure system:Physicochemical characterization,IS particle deposition and clearance in human airway using MPPD model

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Incense smoke(IS)is source of indoor air pollution and key risk for diverse human diseases.Less in-formation is available regarding controlled IS rodent inhalation exposure system and IS particulate matter(PM)deposition in human airways.Study aimed to demonstrate stable ISPM physicochemical parameters of 10 incense products inside the customized whole body inhalation exposure chamber(without animal)connected to smoke generation unit via aerosol mixing device.IS analyzed for size segregated PM emission,ISPM in vitro aerodynamics(MMAD and GSD determination),fine and ultrafine particle's SEM,SEM-EDX and PAH analysis.Using real life exposure scenario by utilizing MMAD,GSD and PM concentration after Tier 1 exposure assessment as key input parameters,ISPM dosimetry in infant(3 months)and adult(21 years male and female)human airways was calculated using multiple-path particle dosimetry(MPPD 3.04)modeling.Mass median aerodynamic diameter(MMAD)and geo-metric standard deviation(GSD)ranged between 0.55 and 2.10 μm and 1.22 to 1.77(polydisperse)respectively.PM1.0 and PM0.1 showed multiple morphology and presence of heavy and trace elements.PAH like acenaphthylene,anthracene,fluorene,naphthalene and phenanthrene were detected(0.84-143.17 μg/g).MPPD results showed higher ISPM deposition in pulmonary region and lowest in trachea bronchial region.ISPM deposition in tissue was higher in lower,peripheral lung as compared to upper and central lung tissue.Whole body inhalation exposure system showed stable IS atmosphere(physi-cochemical parameters)indicating the device suitability in future inhalation studies.MPPD ISPM deposition fraction and clearance data showed deep lung penetrating and retention behavior with higher risk in infant followed by female and then male.These modeled particle deposition and clearance data may be useful in risk assessment analysis of IS.

InhalationIncense smokeMultiple-path particle dosimetry(MPPD)Particle depositionParticulate matter(PM)Mass median aerodynamic diameter(MMAD)Human airway

Vyas Kumar、Hafsa Hashmi、Anshita、Nasreen Ghazi Ansari、Jyotsna Singh

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Inhalation Toxicology Facility,Regulatory Toxicology Group,CSIR-Indian Institute of Toxicology Research,Lucknow,226001,UP,India

Academy of Scientific and Innovative Research(AcSIR),Ghaziabad,201002,UP,India

Analytical Chemistry,Regulatory Toxicology Group,CSIR-Indian Institute of Toxicology Research,Lucknow,226001,UP,India

Director,CSIR-IITRCouncil for Scientific and Industrial Research,New Delhi,Indiafellowship from Council of Scientific and Industrial Research,New Delhi,IndiaCSIR-IITR manuscript

MLP 004IITR/SEC/MS/2023/19

2024

10.1016/j.partic.2023.08.014

颗粒学报(英文版)
中国颗粒学会　中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD
影响因子：0.632
ISSN：1674-2001
年,卷(期)：2024.87(4)
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