首页|Current status and challenges in the application of microbial PHA particles

Current status and challenges in the application of microbial PHA particles

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Polyhydroxyalkanoates(PHAs)are diversiform biopolyesters with a similar structure and different side chain groups,synthesized by a variety of microorganism.Due to their excellent biodegradability and biocompatibility,PHAs have been used for many applications,including medical implants,antibacterial agents and bioengineering.Nano-architecture is an emerging area for the use of PHAs.This review summarizes the current status and challenges of PHAs-based particles on the micro-and nano-scale,including their production,degradation,biological safety,and surface functionalization.We also focus on the applications of PHA particles in drug delivery systems,environment protection,tissue engi-neering,vaccine engineering,food science,biotechnology and cosmetics.Finally,the future development trends of PHAs-based particles are prospected.

Polyhydroxyalkanoates(PHAs)ParticlesSynthetic biologyTissue engineering

Jiaxuan Liu、Ziqi Zhou、Haoru Li、Xinyu Yang、Zeyu Wang、Jian Xiao、Dai-Xu Wei

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Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education,School of Medicine,Department of Life Sciences and Medicine,Northwest University,Xi'an,710069,China

School of Physics and Electronic Information,Shangrao Normal University,Shangrao,334001,China

School of Clinical Medicine,Qujing Medical College,Qujing,655000,China

Zigong Affiliated Hospital of Southwest Medical University,Zigong Psychiatric Research Center,Zigong Institute of Brain Science,Zigong,643002,China

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Key Science and Technology Plan Projects in Zigong国家自然科学基金江西省自然科学基金

2022ZCNKY073190095020212BAB214048

2024

10.1016/j.partic.2023.08.011

颗粒学报(英文版)
中国颗粒学会　中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD
影响因子：0.632
ISSN：1674-2001
年,卷(期)：2024.87(4)
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