首页|The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

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Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical properties.This paper addresses these challenges by preparing microparticles using a blend of starch-chitosan and a poloxamer,commercially named Pluronic® F127.We aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying technique.Blends with a poloxamer concentration of 3％(w/v)demonstrated a notably higher yield,especially when compared to those with 0％and 1％concentrations.Microparticles with 3％and 5％(w/v)poloxamer displayed a narrower particle size distribution,with the 3％blend showing a superior yield attributed to arrangements of blend components that improve flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between components.Microparticles with increased poloxamer content showed elevated thermal degradation temperatures,with the 3％blend registering a significant rise,opening avenues for encapsulating heat-sensitive bioactive.This study primarily focuses on the preparation and basic characterization of microparticles.It underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

BiopolymerStarchChitosanPluronic® F127MicroparticlesSpray drying

Juan Enrique Barranco-García、Carolina Caicedo、Enrique Javier Jiménez-Regalado、Carlos Espinoza-González、Graciela Morales、Rocio Yaneli Aguirre-Loredo、Abril Fonseca-García

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Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca,Departamento de Química y Bioquímica,Avenida Ing.Víctor Bravo Ahuja No.125,Esquina Calzada Tecnológico,68030,Oaxaca,Mexico

Faculty of Engineering,Unidad Central del Valle del Cauca(UCEVA),Carrera 17a 48-144,763022,Tuluá,Colombia

Centro de Investigación en Química Aplicada(CIQA),Blvd.Enrique Reyna Hermosillo 140,25294,Saltillo,Coahuila,Mexico

Investigadoras por México CONAHCYT-CIQA,Av.Insurgentes Sur 1562,Col.Crédito Constructor,03940,Alcaldía Benito Juárez,CDMX,Mexico

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CIQA (Internal call 2022)program Investigadoras por México by CONAHCYT

6710

2024

10.1016/j.partic.2023.10.004

颗粒学报(英文版)
中国颗粒学会　中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD
影响因子：0.632
ISSN：1674-2001
年,卷(期)：2024.89(6)
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