Cocrystals of carbamazepine:Structure,mechanical properties,fluorescence properties,solubility,and dissolution rate

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外文摘要：Carbamazepine(CBZ)is an anticonvulsant with very low water solubility,presenting as a white crys-talline powder with poor mechanical properties and is hard to bend.To enhance CBZ's physicochemical properties,such as water solubility and mechanical properties,we selected six cocrystal coformers(CCFs):nicotinamide(NIC),benzamide(BZM),salicylic acid(SCA),fumaric acid(FMA),trimesic acid(TMA),and hesperetin(HPE).Six CBZ cocrystals were successfully prepared using the solution method.Fourier transform infrared spectroscopy(FT-IR),powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC),and single crystal X-ray diffraction(SCXRD)were used to characterize the crystal structures and gain comprehensive insights into the six cocrystals.The mechanical,fluorescence,and solubility properties of the six cocrystals were tested.The results reveal that most of the prepared cocrystals exhibit improved water solubility and mechanical properties when compared to CBZ.Among them,the dissolution rate of cocrystals excluded from CBZ-HPE has increased by an average of 3 or 4 times compared to CBZ,while CBZ-HPE exhibits superior mechanical properties.Moreover,all six coc-rystals possess better fluorescence performance than CBZ.We thoroughly evaluated the mechanical properties of the cocrystals through both experimental and theoretical approaches.This work provides a new direction for studying drug cocrystals to improve the physicochemical properties of drugs.

外文关键词：

CarbamazepineCocrystalMechanical propertiesFluorescence performanceDissolution rate

作者：

Jinbo Ouyang、Lishan Liu、Yin Li、Mingyang Chen、Limin Zhou、Zhirong Liu、Li Xu、Hamza Shehzad

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作者单位：

School of Chemistry and Materials Science,East China University of Technology,Nanchang 330013,China

School of Physics and Materials Science,Nanchang University,Nanchang 330013,China

School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaTraining plan for academic and technical leaders of major disciplines in Jiangxi Province-Youth Talent ProjectJiangxi Provincial Natural Science FoundationJiangxi Provincial Natural Science FoundationJiangxi Provincial Natural Science FoundationJiangxi Province Key Laboratory of Synthetic Chemistry

项目编号：

220680022217805420212BCJ2300120224ACB21300720212ACB20300220232BBH80015JXSC202209

出版年：

2024

DOI：

10.1016/j.partic.2023.11.016

颗粒学报(英文版)

中国颗粒学会　中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD

影响因子：0.632

ISSN：1674-2001

年,卷(期)：2024.90(7)