首页|Heterogeneous crystallization of Chlorzoxazone for modulating the physicochemical properties of crystals
Heterogeneous crystallization of Chlorzoxazone for modulating the physicochemical properties of crystals
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The polymer on modulating the crystal's habit is an evolving research in pharmaceutical crystallization.This study demonstrates the crystal habit modification of chlorzoxazone(CHZ)by heterogeneous crys-tallization(HC)in the binary solvent acetonitrile-ethanol(A-E(1:1))in the presence of poly-vinylpyrrolidine(PVP)at concentrations of 0.50,0.75,and 1.00 wt％.The A-E(1:1)and PVP in HC experiments influenced to change the shape of crystals from needle to plate shape and reduced the crystal size producing a lower aspect ratio(in the range of 1.5-2.3).In the presence of PVP,the CHZ size distribution is 65-78 pm which tends to enhance the powder flow-ability of CHZ crystals and as the PVP concentration increases,the nucleation rate decreases.The solubility of size-reduced CHZ crystals at different pH is found to be improved by 1.2-1.4 times.Hence,HC is deemed effective in modifying the physicochemical attributes of CHZ.
ChlorzoxazonePolyvinylpyrrolidineHeterogeneous crystallizationCrystal habit modificationAspect ratio
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NSTL
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