首页|Fabrication of micro spherulitic particles of carbamazepine-hesperetin cocrystal via QESD with enhanced manufacturability and dissolution

Fabrication of micro spherulitic particles of carbamazepine-hesperetin cocrystal via QESD with enhanced manufacturability and dissolution

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Granulation is an effective method for improving the flowability of drugs,particularly when they are in needle form.Carbamazepine-hesperetin(CBZ-HPE)cocrystal is a needle-like crystal with low solubility and poor flowability,which limits its application.To address this issue,this study aimed to obtain CBZ-HPE microspheres using the quasi-emulsion solvent diffusion(QESD)technique.The preparation process was monitored using polarized light microscopy,and the formation mechanism was elucidated using the radial distribution function(RDF).The microspheres were extensively characterized using PXRD,DSC,TGA,and SEM.Furthermore,the effects of surfactants,contents,and rotational speeds on the morphology and particle size distribution of microspheres were analyzed to determine the optimal experimental conditions.Based on these findings,naringenin and quercetin,the active ingredients of traditional Chinese medicine,were chosen to successfully prepare CBZ-HPE multicomponent micro-spheres.This research provides a foundation for increasing drug powder properties and drug conjugation through the preparation of microspheres.

Carbamazepine-hesperetin cocrystalQuasi-emulsion solvent diffusion(QESD)techniqueMicrospheresFlowabilityDissolution rate

Jinbo Ouyang、Lishan Liu、Zichen Ning、Zhuoshan Gong、Limin Zhou、Feiqiang He、Zhi Gao、Li Xu、Shichao Du、Huaiyu Yang

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Jiangxi Province Key Laboratory of Functional Organic Polymers,East China University of Technology,Nanchang,330013,China

School of Pharmaceutical Science,Qilu University of Technology,Jinan,250353,China

Department of Chemical Engineering,Loughborough University,Leicestershire,LE11 3TU,UK

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaJiangxi Provincial Natural Science FoundationJiangxi Provincial Natural Science FoundationJiangxi Province Key Laboratory of Synthetic Chemistry

220680022217805420224ACB21300720232BBH80015JXSC202209

2024

颗粒学报(英文版)
中国颗粒学会 中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD
影响因子:0.632
ISSN:1674-2001
年,卷(期):2024.93(10)