首页|Numerically investigation of particle distribution in industrial-scale DTB crystallizer based on CFD modelling

Numerically investigation of particle distribution in industrial-scale DTB crystallizer based on CFD modelling

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The suspension state of crystals in the crystallizer is one of the important indicators for evaluating the adaptability of the crystallizer.This study adopted the Euler-Eulerian two-fluid model to simulate and analyze the fluid motion of solid-liquid two-phase flow in the industrial-grade DTB crystallization kettle,as well as the phase suspension distribution of crystal particles.The main influencing factors investigated are:the heat transfer effect,the height of the bottom of the crystallizer,the number and position of the stirring paddle,crystal size and crystal volume fraction.Based on the research of Euler-Eulerian method to simulate fluids,the Euler-Lagrangian method was further used to simulate the motion state of particle phases with different particle sizes in the crystallizer.It was found that the designed DTB crystallizer has good recycle mixing effect.The particles can be mixed evenly during the operation,which can fully realize the solid-liquid mixing and suspension effect of the drug under study.

Draff tube baffle(DTB)crystallizerTwo-fluid modelNumerical simulationTurbulence modelling

Jinju Ma、Weiyu Wang、Wei Huang、Wei Liu、Xinding Yao、Tao Li、Baozeng Ren

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School of Environment Engineering,Yellow River Conservancy Technical Institute,Kaifeng,475004,China

School of Chemical Engineering,Zhengzhou University,Zhengzhou,450001,China

School of Chemistry and Chemical Engineering,Wuhan University of Science and Technology,Wuhan 430081,China

Kaifeng Engineering Research Center for Municipal Wastewater Treatment,Kaifeng,475004,China

Henan Engineering Technology Research Center of Green Coating Materials,475004,Kaifeng,China

School of Chemical Engineering,Zhengzhou University Zhengzhou,450001,China

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2024 Key Scientific Research Project Plan for Institutions of Higher Education in Henan ProvinceKaifeng City Science and Technology Development Plan Science and Technology Research Project

24A5300062303057

2024

颗粒学报(英文版)
中国颗粒学会 中国科学院过程工程研究所

颗粒学报(英文版)

CSTPCD
影响因子:0.632
ISSN:1674-2001
年,卷(期):2024.93(10)