2型糖尿病个体进行即刻种植即刻修复预后的动物实验研究
Animal experiment of prognosis of immediate implant placement and restoration in individuals with T2DM
赵国强 1宋应亮2
作者信息
- 1. 口颌系统重建与再生全国重点实验室 国家口腔疾病临床医学研究中心 陕西省口腔生物工程工程技术研究中心 空军军医大学第三附属医院口腔种植科,西安 710032;空军杭州特勤疗养中心疗养五区疗养一科,无锡 214128,江苏
- 2. 口颌系统重建与再生全国重点实验室 国家口腔疾病临床医学研究中心 陕西省口腔生物工程工程技术研究中心 空军军医大学第三附属医院口腔种植科,西安 710032
- 折叠
摘要
目的 通过建立动物模型,验证2 型糖尿病个体即刻种植即刻修复的可行性,并评估其预后.方法 应用新西兰兔构建2 型糖尿病动物模型作为实验组,以健康新西兰兔为对照组,2 组均进行即刻种植即刻修复,通过Micro-CT扫描、硬组织切片染色及分析、实时定量PCR检测炎症相关因子,对比2 组的预后及组织学改建有无差异.结果 2 组实验兔即刻种植即刻修复后种植体留存率均为90%,术后早期(2 个月内)实验组种植体周骨质在各项微观参数中与对照组存在显著差异,同时术后1个月实验组种植体周软组织内IL-6、IL-33与TNF-α的表达显著高于对照组.结论 动物实验表明2 型糖尿病动物模型应用即刻种植即刻修复后具有较好的安全性,但种植体早期骨结合形成缓慢、种植体周软组织炎症更为明显.
Abstract
Objective To investigate the feasibility and prognosis of immediate implant placement and immediate restoration in patients with type 2 diabetes by establishing an animal model.Methods The type 2 diabetic animal model was established using New Zealand rabbits as the experimental group and healthy New Zealand rabbits as the control group.Both groups underwent immediate implantation and immediate repair.Micro-CT scanning,hard tissue section,and detection of relative inflammatory factors by real-time quantitative PCR were used to compare prognosis and histological remodeling between the two groups.Results The success rate for immediate implant placement and immediate restoration was 90%in both groups.In the early postoperative period(1～2 months),the peri-implant bone of the experimental rabbits in the T2DM group was significantly different from the control group in various microscopic parameters,in the meantime,the expressions of IL-6,IL-33 and TNF-α were significantly higher than those of the control group.Conclusion Animal experiments have shown that the immediate implant placement and immediate prosthesis are safe in type 2 diabetic animal models.However,attention should be paid to the slow formation of osseointegration and obvious inflammation of the soft tissue around the implant in the early stage.
关键词
口腔种植/即刻种植/即刻修复/动物实验/2型糖尿病Key words
Dental implant/Immediate implant placement/Immediate restoration/Animal experiment/Type 2 diabetes mellitus引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据