From Phylogenetics to Phylogenomics: a Brief Review to the Evolutionary Researches of Yersinia pestis
Since 1990s,genomics has been serving a more and more important role in bacterial researches,especially in the evolutionary studies of pathogens.Numerously novel findings in this area are achieved with the accumulation of the flooding genomics data.Here we focused on the history of evolutionary researches of an important human pathogen,Yersinia pestis,which undergoes dramatic changes from the traditional phylogenetics analysis based on polymorphisms of specific alleles in genomes,to the phylogenomics studies involving whole genome-wide variations of large amount of strains.