Post-transcriptional chemical modifications are prevalent in various RNA molecules and play a profound role in biological functions,including the regulation of RNA splicing,translation,transport,localization,and stability.Recent advancements in high-throughput sequencing and chemical modification detection technologies have facilitated significant breakthroughs in accurately identifying and localizing different RNA modifications,such as m6A,m5C,and m1A.As a novel category of epigenetic transcriptional biomarkers,RNA modifications have garnered considerable attention in the diagnosis and treatment of numerous diseases,including tumors,neurological diseases and immunological diseases.This review aims to provide a comprehensive overview of the biological roles of RNA modification and editing,the underlying molecular mechanisms regulating protein expression and further highlight the progress in the application of RNA modification in disease diagnosis and treatment.
NETL
NSTL
万方数据
维普
