Hepatocellular carcinoma(HCC)is a worldwide malignancy with high incidence,rapid growth,early metastasis and high mortality.Non-coding RNA(ncRNA)refers to a class of RNA that is transcribed from the genome and does not code for proteins.They are abundant,accounting for about 80％of eukaryotic cell transcripts.Recent studies have revealed that ncRNAs can regulate gene expression at the epigenetic,transcriptional,and post-transcriptional levels,or regulate the localization,activity,and function of proteins,thereby affecting cell activity,like differentiation,proliferation,death,motility,and so on.A deeper understanding on the ncRNA regulatory networks in HCC development and progression will provide new strategies for the diagnosis and treatment of HCC.In this review,we introduce the classification of ncRNA,the mechanism of ncRNA biogenesis,processing,and degradation,and the functional network of ncRNAs.We also summarize recent findings on how ncRNAs regulate the malignant phenotypes of HCC.Finally,we discuss the potential applications of ncRNA as diagnostic biomarkers and therapeutic targets.
NETL
NSTL
万方数据
维普
