Brucellosis is a significant zoonotic infectious disease caused by intracellular Brucella.It is prevalent worldwide,particularly in the Middle East and Asia,and China is no exception.Upon invading the host,the Gram-negative Brucella effiiciently colonizes macrophages,evading the host's immune system and inducing chronic infections in humans,various domestic animals,and wild lives,and finally leading to comparable clinical symptoms and pathological lesions.This not only poses a threat to animal and human health but also profoundly impacts economic development and social stability,even posing a potential threat to national security.Strengthening scientific research and implementing integrated prevention and control measures for brucellosis hold significant importance for both the economy and public health,forming a crucial component of the national security strategy.The prevention and control of infectious diseases rely on the foundational principles of"Eliminating the source of infection,protecting susceptible hosts,and severing transmission routes."Among which,robust monitoring,reliable diagnosis,and the development of safe and effective vaccines hold particular significance.Since 1950,China has established scientific research teams dedicated to investigating and researching brucellosis,jointly addressing key challenges,implementing comprehensive prevention and control measures in a staged and systematic manner,which leads to fruitful outcomes and the accumulation of valuable experience and insights.Notably,we have formulated and updated industry and national standards for brucellosis diagnostic techniques,culminating in the development of Brucella CELISA,IELISA,and colloidal gold test kits(strips),all of which have secured new veterinary drug certifications.Simultaneously,China has achieved a significant breakthrough by independently developing the Brucella attenuated vaccine.The conventional attenuated Brucella vaccines(M5,S2,and M5-90)and gene-deleted live vaccines(A19-ΔVIRB12,M5-90Δ26,and BA0711)have been approved and utilized.The widespread adoption and application of these research findings provide crucial scientific and technical support for effectively controlling and ultimately eradicating Brucella.
brucellosiszoonosisvaccinesdiagnosisprevention and control
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