Epidemic prevention and control of porcine pseudorabies in China
Porcine pseudorabies poses a significant threat to the pig industry as a major infectious disease.In 1979,the Bartha-K61 live vaccine was introduced to China as an effective measure to control this disease.However,in 2011,pseudorabies outbreaks occurred in numerous immunized pig farms,indicating that the existing vaccine could not fully protect against the newly isolated virus strains after immunization.In response to this challenge,Chinese researchers have been diligently conducting epidemiological surveillance on PRV variants.To date,PRV mutants have been detected in 29 provinces across China.Sequence analysis has revealed that these newly prevalent strains are genetically distinct from the gene type Ⅰ strain(found abroad)and the early Chinese classical strain.Notably,characteristic amino acid variations specific to the PRV variants have been identified.Consequently,efforts have been made to develop vaccines and diagnostic reagents that target these new epidemic strains.Several organizations have successfully developed inactivated vaccines and diagnostic kits for the PRV mutants,and obtained certifications of new veterinary drugs.Furthermore,significant progress has been achieved in the development of gene-deletion attenuated live vaccines.These advancements in research provide valuable theoretical and technical support for the prevention,control,and eradication of porcine pseudorabies.
万方数据
维普
