Well balanced and timed metabolism is essential for oocyte development.The effects of extrinsic nutrients on oocyte maturation have been widely reported,but intrinsic control of oogenesis by intracellular metabolites and metabolic enzymes has received little attention.The comprehensive characterization of metabolic patterns could lead to more complete understanding of regulatory mechanisms underlying oocyte development.Recently the close contact between cellular metabolism and epigenetic modifications has been widely reported.In addition,oocytes metabolic disorders caused by changes in the maternal environment may affect early embryonic development and offspring health through epigenetic modifications.Here we summarize the findings on metabolic regulation in oocyte maturation.And we discuss the potential mechanisms of maternal environmental abnormalities affecting offspring health from the perspective of oocyte epigenetic modification,with a view to improving oocyte quality and female reproduction.
oocytemetabolismmaternal environmentepigeneticsreproductive health
万方数据
维普
