Manchette is a transient microtubule-and F-actin-based structure during spermiogenesis.The period when the manchette is formed is crucial for sperm head shaping,acrosome formation and flagellum assembly.Overall,the formation and elimination of manchette,the connection between manchette and the nucleus,and the intra-manchette protein transport are essential for spermiogenesis.More than 100 manchette-related proteins have been discovered in animal models by using multi-omics methods,but the specific molecular mechanisms and related regulatory networks of these proteins are mostly unclear.In this review,we provide a systematic overview of the biological processes involved in manchette,focusing on the role of manchette in sperm head shaping and flagellar assembly,updating the protein spectrum and possible molecular networks involved in manchette,and summarizing the research progress of manchette-related causative genes associated with male infertility,which will help to promote further research on manchette during spermiogenesis.
维普
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