The role of spermiogenesis-related genes in the occurrence of oligoasthenoteratozoospermia
Infertility is a major problem in human reproductive health.It is estimated that about 10％～15％of child-bearing couples worldwide are affected by infertility,with male factors accounting for half of these.The production of sperm with normal morphology and function is the basis of human reproduction.Spermatogenesis includes three stages:mitosis,meiosis and spermiogenesis.Among them,spermiogenesis is a unique stage of male germ cell development.Some studies have shown that defects of spermiogenesis-related genes are closely associated with oligoasthenoteratozoospermia(OAT),which is a common type of male infertility.In recent years,it has been reported that abnormalities in spermiogenesis-related genes lead to OAT phenotypes in humans and mice.However,the role of spermiogenesis-related genes in the development of OAT has not yet been systematically summarized.This review focuses on the key events in spermiogenesis and the roles of some representative related genes in the occurrence of OAT,in the hope of providing better assistance for fertility counselling,treatment,and pregnancy assistance for OAT-affected men.
万方数据
维普
