Mitochondria play a critical role in cellular energy production,and mutations in mitochondrial DNA(mtDNA)can lead to mitochondrial diseases.Mitochondrial dysfunction affects tissue and organ functions and significantly impacts individual development,especially in non-renewable cells and tissues.Recent advancements in gene editing technology have opened up new possibilities for treating individuals born with mitochondrial diseases,while this technology has no way to block the transgenerational transmission of mitochondrial diseases.Mitochondrial replacement during embryo formation,combined with assisted reproductive technology(ART),offers a promising approach to preventing the inheritance of mitochondrial diseases.This article discusses the feasibility of using mitochondrial replacement technology(MRT)during ART to block the occurrence and inheritance of mtDNA mutations from the perspectives of effectiveness,safety,and limitations.
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