Advances in bio-manufacturing of food functional factors based on regulating cell growth of model microorganism
As the basic materials of functional food manufacturing,food functional factors are the physiological activators which play a vital role in regulating human performance,improving sleeping and accelerating growth.Synthetic biology,as a safer,healthier and sustainable approach to obtain food,has become the important technical support to promote the development of food industry.The synthetic pathway of food components is designed and constructed by synthetic biological technology in food synthetic biology,then an intelligent cell factory with food industry application capability is created.The synthesis efficiency of food functional factors and other high value-added products will be greatly improved.At present,the model microorganisms such as Escherichia coli,Bacillus subtilis,Corynebacterium glutamicum and Saccharomyces cerevisiae are regarded as synthetic carriers of food functional factors.The bio-manufacturing of food functional factors has made great progress by finely regulating cell growth.This review summarized the current research strategies and progress in the synthesis of food functional factors based on regulating cell growth of model microorganism.We mainly focused on the aspects of improving the growth rate by transporters engineering,reprogramming cell energy metabolism,balancing cell growth and product synthesis.Finally,the current challenges were put forward and the future development was prospected.
万方数据
维普
