首页|基于基因组结构变异解析动物复杂性状的研究进展

基于基因组结构变异解析动物复杂性状的研究进展

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动物为了适应环境而演化出多种多样的表型性状.揭示物种复杂性状的分子机制对理解物种适应性演化至关重要.基因组结构变异是动物复杂性状重要分子机制之一,它反映了基因组不同位置和序列的可变性,包括大片段的平衡变异倒位、易位,以及非平衡变异插入、缺失和重复等多种多样变异类型.相对于单碱基变异和小片段插入缺失,基因组结构变异在基因组上影响的碱基范围更广,对动物复杂性状的影响更大.本文通过对基因组结构变异的类型和结构变异的检测鉴定技术的研究历史进行概述,并从动物毛色性状、极端环境适应性状和驯养动物经济性状等方面综述基因组结构变异与复杂性状关联的研究进展,为从基因组结构变异的角度解析动物复杂性状产生的分子机制提供重要参考.
Research progresses in revealing complex traits of animals based on genomic structural variations
Animals have evolved a wide variety of phenotypic traits to adapt to their environment.Among the molecular mechanisms of trait evolution,genomic structural variation is one of the important driving forces affecting complex traits in animals,which reflects variability at different locations and sequences in the genome,including a wide range of variant types such as large segment balanced variant inversions and translocations,and unbalanced variant insertions,deletions and duplications.Compared with single-base variants and small insertion deletions,genomic structural variants affect a wider range of DNA sequences in the genome and have a greater impact on complex traits in species.In this article,we will summarize the types of genomic structural variants and the development history of techniques for their detections and identifications,and review the research progress on the association between genomic structural variants and complex traits in terms of animal coat color traits,extreme environmental adaptations,and economic traits of domesticated animals,to provide important references to analyze the molecular mechanisms of complex traits from the perspective of genomic structural variants.

genomic structural variationcomplex traitsanimalsadaptive evolution

汪亚军、王晓萍、于黎

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云南大学,生命科学学院,省部共建云南生物资源保护与利用国家重点实验室,昆明 650091

基因组结构变异 复杂性状 动物 适应性进化

国家自然科学基金国家自然科学基金国家自然科学基金云南省科技厅应用基础研究计划面上项目

322300133192500632360120202001BB050058

2024

中国科学(生命科学)
中国科学院

中国科学(生命科学)

CSTPCD北大核心
影响因子:0.725
ISSN:1674-7232
年,卷(期):2024.54(2)
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