Preparation of ultrasmall-sized Ag in synergy with Cu-based ferrite composite and its antibacterial activity against Staphylococcus aureus
Nano-silver(Ag)with ultra-small particle sizes have strong antibacterial activity because it can pass through the bacterial cell wall and enter the internal environment,causing irreversible damages to bacteria,but the disadvantages such as easy agglomeration and high toxicity limit its application.In this study,Fe3O4/Cu/CuO carriers(F)were prepared using Fe and Cu compounds with high biocompatibility,and mesoporous(m)ZrO2 was coated on the surface of the carriers to synthesize Fe3O4/Cu/CuO@mZrO2 nanocomposites(FZ).Then～3 nm Ag was loaded on the surface of FZ to prepare core-shell Fe3O4/Cu/CuO@mZrO2@Ag(FZA)composite materials,which not only solved the problem of Ag agglomeration,but produced strong antibacterial properties with ROS(-OH)and Cu released by Fenton reaction.The results showed that 150 μg/mL FZA inhibited 99.99％of Staphylococcus aureus(S.aureus)and Methicillin-resistant Staphylococcus aureus(T-S.aureus)after 40 min treatment.It could effectively disrupt the bacterial cell wall and lead to nucleic acid and cytoplasmic leakage,which consequently induced bacterial apoptosis.In the meantime,the toxicity of FZA to somatic cells was reduced by 1/2 when compared with that of single Ag.Therefore,FZA could be used in dressing studies on account of its strong antibacterial properties.
万方数据
维普
