The development of cerebral vasculature and related diseases
The maintenance of normal brain development and function is attributed to the unique anatomical structure,physiological function,and homeostasis maintenance mechanism of the cerebral vascular network.This network is regulated by various molecules,such as VEGF,NRP1,and TGF-β.Cerebrovascular diseases and neurodegenerative diseases(e.g.,cerebral arteriovenous malformation and Alzheimer's disease)can occur due to abnormal or impaired cerebrovascular development.The understanding of these diseases has improved in the past decades,but their pathogenesis remains unclear,therefore safer and more effective treatment strategies for these diseases are urgent to be developed.Animal models have become a crucial tool for exploring the pathogenesis and physiological characteristics of central nervous system diseases.This review focuses on the latest progress on cerebrovascular development and its regulation mechanism,cerebrovascular diseases,and cerebrovascular diseases models,which will provide valuable reference for basic and clinical research involving cerebrovascular diseases.
cerebrovascular developmentmolecular regulationcerebral arteriovenous malformationAlzheimer's diseasecerebrovascular disease model
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