Manipulation of the cellular cytoskeleton-membrane network for virus replication
Epidemics caused by viral infections pose a significant global threat to human health and economy.A common feature of virus infection is to reshape the membrane structure and cytoskeleton structure of host cells to form specific organelle-like structures for virus genome replication,which is called viral factory.Different viruses may hijack different organelles to form replication factories,including viroplasm,spherules,double membrane vesicles,tubes and nuclear viral factory.Virus infection can also induce drastic rearrangement of cytoskeleton,forming cage-like structures to wrap the virus factory,including actin ring,microtubule cage and intermediate filaments cage.This review systematically summarizes the formation process of virus factory and the corresponding morphological changes of cytoskeleton and membrane network.Specifically,we focus on the functions of material transport,physical support,and biochemical regulation of cytoskeleton and their related proteins during the establishment of virus factory.We also discuss the importance of these interactions in the context of viral replication and future research directions.
viral replicationviral factorycytoskeletonactin filamentmicrotubuleintermediate filamentrearrangement of cellular membranes
万方数据
维普
