The intrinsic viscoelasticity of natural extracellular matrix and soft tissues of living organisms is a key factor in regulating cell behavior and tissue repair and regeneration.Dynamic polymeric hydrogels based on cross-linking of dynamic constructs can effectively mimic the viscoelastic mechanical microenvironment of in vivo cells or tissues,providing an important tool to regulate cell fate in vitro and reveal their mechanobiological response mechanisms,as well as providing a biomimetic scaffold material for tissue repair and regeneration.Based on the introduction of natural extracellular matrix and viscoelasticity of biological soft tissues,this review focuses on summarizing the design ideas,performance characterization and influencing factors of dynamic hydrogel materials,revealing the mechanisms of the viscoelastic microenvironment affecting cellular and tissue behavior.Finally,the existing problems in this field are analyzed and the future development direction is prospected.This review will help to inspire the design ideas of biomimetic functionalization of polymer hydrogels and the study of biological effects of materials,and further expand the biomedical applications of polymeric hydrogel materials.
维普
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