Progress in RNA mediated intergenerational/transgenerational epigenetic inheritance of acquired traits
The concept of inheritance of acquired traits has been controversial since it was proposed in the early 19th century,and it was not until recent decades that scientists began to revisit and explore the authenticity of this concept.Recently,researchers have been dedicated to identifying the epigenetic information carriers,the inheritance laws and the regulatory mechanisms of intergenerational/transgenerational epigenetic inheritance of parentally acquired traits.As novel epigenetic regulators,non-coding RNAs show multidimensional capability in regulating gene expression,and play indispensable roles in regulating stem cell fate determination and self-renewal,cell proliferation and apoptosis.In recent years,it has also been found that non-coding RNAs and RNA modifications can be served as epigenetic information carriers to transmit the parentally acquired traits to the offspring,providing new research insights and perspectives for the mechanical exploration of epigenetic inheritance of acquired traits.In this review paper,we will comprehensively summarize the functional roles and molecular mechanisms of RNA in regulating intergenerational/transgenerational epigenetic inheritance of acquired traits in view of the recent research progress in this rising field.
RNAepigenetic inheritance of acquired traitssperm RNA code signatureepigenetic regulation
万方数据
维普
