Oral administration of the herbal oligonucleotide XKC-sRNA-h3 prevents angiotensin Ⅱ-induced hypertension in mice
Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeutic agents for various diseases.In the present study,we aimed to demonstrate that a herbal small RNA(sRNA),XKC-sRNA-h3(B55710460,F221.I000082.B11),exhibits potent antihypertensive effects by targeting angiotensin-converting enzyme(ACE)in mice.When compared with captopril,oral administration of the sphingosine(d18:1)-XKC-sRNA-h3 bencaosome more effectively prevented angiotensin Ⅱ-induced hypertensive cardiac damage and alleviated kidney injury in mice.Such findings indicated that XKCsRNA-h3 may be a novel orally available ACE inhibitor type oligonucleotide drug for hypertension.
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