Integrated multi-omics profiling uncovers potential molecular anhydrobiology of tardigrades
This research delves into the molecular mechanisms that allow tardigrades to survive extreme dehydration.We collected genome data of 3 tardigrade species and 11 other metazoa and used OrthoFinder to identify 4 expanded gene families in tardigrades.Multiple bioinformatics techniques were employed to annotate 12899 genes of Ramazzottius varieornatus and determine 5032 differentially expressed genes in the hydrated and various dehydrated states.Additionally,these DEGs were divided into 9 clusters by Fuzzy C-Means algorithms,and those showing upregulated expression during anhydrobiosis were further evaluated in terms of molecular functions.After all,we concluded that the enzyme UGT72E1 may help tardigrades enhance the tolerance to dehydration by participating in the phenylpropane metabolism.This finding was verified by another tardigrade species.
water beartardigradedesiccation toleranceanhydrobiosisUDP-glucuronosyltransferasephenylpropanes metabolism
NETL
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万方数据
