The establishment and applications of the Immortal Cell Banks of Chinese ethnic groups
Human genetic resources are of great research significance.Different ethnic groups in China have their characteristics in terms of ethnic origin,settlement,language,culture,and customs.Due to the difference in founder effect,geographical environment and lifestyle,there are differences in physiological phenotype and disease susceptibility among the Chinese ethnic groups,which provides rich materials for medical and health research.For more than 20 years,the Immortal Cells Bank of Chinese Ethnic Groups has been supported by the National Natural Science Foundation of China and by the Ministry of Science and Technology of the People's Republic of China.So far the cell bank includes a total of 6126 immortalized cell lines from 49 Chinese ethnic groups,which include more than 90 Chinese ethnic subgroups.As an important national strategic resource,the Chinese immortal cell bank and the nucleic acids derived from it provide research materials for the applied researches of genetic structural characteristics,gene variation,expression and function of the Chinese populations,demonstrating the progress in discoverying drug,vaccines and antibodies,and the application potential in stem cells research.In summary,the Immortal Cells Bank of Chinese Ethnic Groups has significantly promoted China's international exchanges and cooperation on human genetic resources.With the development of advanced technologies such as high-throughput sequencing and gene editing,it will provide more resources and tools for human life science research and clinical translation applications.
human genetic resourcesethnic groupsgenetic diversitylymphoblastoid cell bankdisease genesvaccines and medicines
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