中国出生队列生物样本资源建设进展
Progress in biological sample resources development of birth cohort in China
杜江波 1周昆 2林苑 3蒋杨倩 3柯康 1马红霞 1夏彦恺 4胡志斌 1沈洪兵1
作者信息
- 1. 南京医科大学生殖医学与子代健康全国重点实验室,南京 211166;南京医科大学公共卫生学院,全球健康研究中心,流行病学系,南京 211166
- 2. 南京医科大学生殖医学与子代健康全国重点实验室,南京 211166
- 3. 南京医科大学生殖医学与子代健康全国重点实验室,南京 211166;南京医科大学公共卫生学院,全球健康研究中心,流行病学系,南京 211166;南京医科大学公共卫生学院儿少卫生与妇幼保健学系,南京 211166
- 4. 南京医科大学公共卫生学院,全球健康研究中心,流行病学系,南京 211166;南京医科大学公共卫生学院毒理学系,南京 211166
- 折叠
摘要
我国近年来人口自然增长率持续下降,不孕不育发生率居高不下,辅助生殖治疗对子代人口健康的影响尚不完全清楚.因此,生殖和妇幼健康相关研究的重要性日益凸显.出生队列研究是专门用于研究生命早期暴露对孕期和子代近、远期健康影响的经典人群研究设计,已经被用于研究生命早期遗传、环境、社会心理、营养等因素对妊娠结局和子代结局的影响.作为一个复杂的研究资源平台,多个国家已经在该领域取得显著的成效.我国也积极尝试出生队列建设,取得一些成功经验,积累大量的生物样本资源,这些生物样本资源对于将来探索生殖和妇幼健康相关重大科学问题奠定坚实基础.本文全面介绍了国内外出生队列及其生物样本资源建设进展和面临的挑战,展望了出生队列生物样本资源建设发展方向和未来前景,以期为我国人口高质量发展提供重要借鉴与参考.
Abstract
The natural population growth rate in China has continued to decline in recent years,and this trend may continue in the foreseeable future.The incidence of infertility remains high,and the impact of assisted reproductive therapy on the health of the offspring is not fully evaluated.Therefore,reproductive health,maternal and child health related research needs to be strengthened urgently.Birth cohort,a classical study design for association study between maternal exposure and health of offspring,has been used to explore the impact of genetic,environmental,psychosocial,nutritional and other factors on pregnancy outcomes and offspring outcomes in early life.As a complex research platform,several countries have made remarkable achievements in birth cohort.In China,several birth cohorts have started.We have gained some successful experience and accumulated a large number of biological samples,which is critical important for reproductive health,maternal and child health related research.In this review,we comprehensively introduced the progress as well as challenges of birth cohort and biological sample resources in China and globally.We also we look forward to the future of biological sample resources in the birth cohort,with a view to providing important reference for the high-quality development of Chinese population.
关键词
出生队列/生物样本/人类遗传资源/共享合作Key words
birth cohort/biological sample/human genetic resources/sharing and cooperation引用本文复制引用
基金项目
国家重点研发计划(2021YFC2700600)
国家重点研发计划(2021YFC2700705)
出版年
2024
NETL
NSTL
万方数据