Current progress in the detection technologies for prenatal screening and diagnosis of trisomy 21
Trisomy 21(Down syndrome,DS)is one of the most common chromosomal abnormalities,which is considered as a major cause of fetal abortion,malformation,abnormality,and death.So far,there is no effective way for the treatment of children with DS,abortion is the only acceptable method.Therefore,prenatal detection would be necessary.Researchers have developed a variety of prenatal screening and diagnostic techniques,and some of these have been applied in clinical detection,but their sensitivity,accuracy,and costs require further optimization.At the same time,investigating the pathogenic mechanism and biological characteristics of DS and establishing non-invasive diagnostic methods with high sensitivity and high accuracy for DS would be necessary in the future.
Down syndromechromosome abnormalityprenatal screeningprenatal diagnosisdetection techniques
万方数据
维普
