New insights into the immunoregulatory role of SOD3
Superoxide dismutase 3(SOD3)is an antioxidant enzyme that acts outside of cells.Its primary function has been believed to convert superoxide into hydrogen peroxide and oxygen.Recent studies indicated SOD3 also participates in sophisticated immune regulation in diverse diseases.Host-derived SOD3 plays a direct role in modulation of immune processes,including oxidative stress,immune cell maturation,proliferation,differentiation,and inflammation.Pathogens can also express SOD3 to evade host immune defense and facilitate invasion by suppressing host cellular responses.SOD3 expression levels are linked to the progression of immune-related diseases,making it a potential target for immunotherapy.This article thoroughly reviewed the research progress and current knowledge in the immunomodulatory mystery of SOD3.
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