Endoplasmic reticulum-mitochondrial interaction and calcium homeostasis
The endoplasmic reticulum(ER)is one of the largest organelles in the cell,and is the main site of protein synthesis and transport,protein folding,lipid and steroid synthesis,as well as the intracellular calcium reservoir.Mitochondria are intracellular energy factories involved in apoptosis regulation,redox homeostasis,biosynthesis,and signal transduction,and they also play a key role in the maintenance of calcium homeostasis.The endoplasmic reticulum and the outer mitochondrial membrane are in physical contact with each other in a structure known as mitochondria-associated endoplasmic reticulum membranes(MAMs).MAMs play a central role in a variety of cellular pathways,including mitochondrial dynamics,autophagy,inflammation,lipid metabolism,calcium homeostasis etc,and are closely related to the development of many diseases.This article introduces the structure and molecular composition of MAMs and focuses on the role of MAMs in calcium homeostasis.
mitochondrialendoplasmic reticulummitochondrial related endoplasmic reticulumcalcium homeostasis
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