首页|脓毒症免疫抑制与肠道菌群失调

脓毒症免疫抑制与肠道菌群失调

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晚期脓毒症患者长期的免疫抑制是其高死亡率的主要原因.持续的免疫抑制不仅不利于对原始感染源的控制,还增加多重耐药菌和条件致病菌二次感染的风险.逆转脓毒症患者的免疫抑制状态对于改善其生存率具重要意义.肠道菌群失调可通过多种机制增加个体对脓毒症的易感性.本综述旨在探讨脓毒症免疫抑制的机制,分析肠道菌群在其中的角色,特别是对脓毒症免疫抑制的形成和进展的可能影响.
Sepsis immunosuppression and gut microbiota dysbiosis
Prolonged immunosuppression in patients with late-stage sepsis is a key factor of their high mortality rate.Persistent immunosuppression is not only detrimental to the control of the original source of infection but also increases the risk of secondary infections by multidrug-resistant bacteria and opportunistic pathogens.Reversing the immunosuppressive state in sepsis patients is crucial for improving their survival rate.Gut microbiome dysbiosis can increase the susceptibility to sepsis through various mechanisms.This review aims to discuss the mechanisms of sepsis-induced immunosuppression and analyze the role of the gut microbiota,particularly its potential impact on the formation and progression of sepsis-induced immunosuppression.

sepsisgut microbiota dysbiosisimmunosuppression

郭禹彤、张华莉、成丽琴、刘德培

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中南大学基础医学院病理生理学系,长沙 410078

中国医学科学院基础医学研究所,北京协和医学院基础学院,重大疾病共性机制研究全国重点实验室,北京 100005

脓毒症 肠道菌群失调 免疫抑制

2024

中国科学(生命科学)
中国科学院

中国科学(生命科学)

CSTPCD北大核心
影响因子:0.725
ISSN:1674-7232
年,卷(期):2024.54(11)