Prolonged immunosuppression in patients with late-stage sepsis is a key factor of their high mortality rate.Persistent immunosuppression is not only detrimental to the control of the original source of infection but also increases the risk of secondary infections by multidrug-resistant bacteria and opportunistic pathogens.Reversing the immunosuppressive state in sepsis patients is crucial for improving their survival rate.Gut microbiome dysbiosis can increase the susceptibility to sepsis through various mechanisms.This review aims to discuss the mechanisms of sepsis-induced immunosuppression and analyze the role of the gut microbiota,particularly its potential impact on the formation and progression of sepsis-induced immunosuppression.
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