Genetic etiology and neurobiological mechanisms of autism spectrum disorders
Autism spectrum disorder is a common neurodevelopmental disorder that seriously affects children's health,characterized by deficits in social interactions and repetitive behavior/restricted interests.There is no effective treatment,which brings heavy burden to society and families.Therefore,it is of great theoretical and practical significance to study the etiology of autism and explore new ways to prevent and cure autism.The causes of autism are complex,and both genetic and environmental factors are involved.Systematic studies on the function of autism risk genes have revealed the underlying neurobiological pathologic mechanisms and involved common signaling pathways of autism.More and more evidence shows that gene-environment interaction plays an important role in the etiology of autism,which will provide a possible new entry point for autism research.In addition,the application of animal models has promoted the rapid development of autism etiology research,and drug development,so it is necessary to develop new animal models.In-depth understanding of the pathogenesis of autism will promote the discovery of biomarkers or therapeutic targets,and provide theoretical basis and necessary support for the"early diagnosis,early warning and early intervention"of autism.
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