Advancements and prospects in human organoid phenomics:a comprehensive review
Human organoids are three-dimensional(3D)in vitro cell cultures that accurately mimic the cell types,tissue structures,and other essential characteristics of human organs.Human organoids can partially simulate the development process of human organs.Consequently,they are extensively utilized in research concerning biological phylogeny,disease mechanisms,drug screening,and drug toxicology.In this review,we summarized the methods and advancements in using phenomics to study human organoids,and outline prospects for their future development and application.
three-dimensional human organoidsphenomicsdrug screeningdisease researchgenetic research