Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by the production of anti-nuclear antibodies and widespread organ inflammation.The pathogenesis of SLE is not yet fully understood,however,recent research have increasingly focused on the role of epigenetic regulation and post-translational modifications in this disease.Among these,ubiquitination,as an important form of protein modification,plays a key role in maintaining protein homeostasis and the balance of protein-protein interactions.Deubiquitinating enzymes(DUBs),by regulating the homeostasis of key target proteins,have exerted profound effects on the pathogenic mechanisms and progression of SLE.This review aims to provide insights into the existing research on SLE and deubiquitination,focusing on molecular mechanisms,with the goal of providing new perspectives for the development of novel therapeutic targets for SLE.
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