中国科学(生命科学)2024,Vol.54Issue(11) :2181-2187.DOI:10.1360/SSV-2024-0141

色素颗粒是皮肤型红斑狼疮的敏感性皮肤镜特征

Pigment granules are sensitivity dermatoscopic feature in diagnosis cutaneous lupus erythematosus

鲁丽霞 赵雪 陈明亮 陈翔 粟娟
中国科学(生命科学)2024,Vol.54Issue(11) :2181-2187.DOI:10.1360/SSV-2024-0141

色素颗粒是皮肤型红斑狼疮的敏感性皮肤镜特征

Pigment granules are sensitivity dermatoscopic feature in diagnosis cutaneous lupus erythematosus

鲁丽霞 1赵雪 1陈明亮 1陈翔 1粟娟1
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作者信息

  • 1. 中南大学湘雅医院皮肤科,皮肤肿瘤与银屑病湖南省重点实验室,长沙 410008;湖南省皮肤健康与疾病工程研究中心,长沙 410008;国家老年疾病临床研究中心,中南大学湘雅医院,长沙 410008
  • 折叠

摘要

皮肤型红斑狼疮(cutaneous lupus erythematosus,CLE)的病变具有高度异质性.因为它是根据常见的临床特征和相似的治疗反应进行分类的,病变主要以瘢痕愈合为主.所以CLE的早期诊断至关重要,皮肤镜检查可以实现早期诊断并且有助于评估已有病变的病情.我们采用回顾性分析的方法,分析了90例确诊为CLE的病例,并进行了病理活检和皮肤镜检查.统计病例获得了详细的人口学信息、病理和皮肤镜检查数据,分析发现,色素颗粒、多形性扩张的血管、毛囊角栓和白色无结构区/白色纤维条索是诊断CLE最有特征的皮肤镜表现.多形性血管主要包括蛇形、点状、线状、螺旋状和发夹状等.血管的分布模式主要是在毛囊周围,即红点征,其他分布模式包括局灶分布模式、均匀模式、中心模式、周围分布模式.

Abstract

Lesions of cutaneous lupus erythematosus(CLE)is highly heterogenous.CLE is categorized based on very common features and similar responses to treatment,lesions are mainly heal with scaring.Early diagnosis of CLE is crucial,dermoscopy may enable early diagnosis and help to assess the prognosis of well-established lesions.Retrospective analysis of 90 CLE cases under dermoscopy and pathological biopsy was performed.Cases were reviewed for information regarding pathological and dermoscopy pattern.Dermoscopy was performed using Medicam 800/1000(FotoFinder,Germany)at 20~70× magnification in non-polarized mode.Pigment granules,multiform dilated vessels,follicular keratotic plugs and white structureless areas/white fiber cord are the most featured dermoscopic manifestations in the diagnosis of CLE.The multiform dilated vessels including serpentine,punctate,linear,spiral and hairpin.The distribution pattern of vessels is mainly around follicles,that is red dot sign,other distribution patterns including focal distribution pattern,uniform mode,central mode,peripheral distribution pattern.

关键词

皮肤型红斑狼疮/色素颗粒/皮肤镜/组织病理

Key words

cutaneous lupus erythematosus/pigment granules/dermatoscopy/dermatopathology

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出版年

2024
中国科学(生命科学)
中国科学院

中国科学(生命科学)

CSTPCDCSCD北大核心
影响因子:0.725
ISSN:1674-7232
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