EB病毒(Epstein-Barr virus,EBV)属于Y疱疹病毒亚科,在人群中广泛流行,与鼻咽癌、胃癌和淋巴瘤等多种恶性肿瘤的发生密切相关.然而,EBV致瘤的分子机制仍不清楚.EBV非编码RNA包括EBV长非编码RNAs(EBV long non-coding RNAs,EBV lncRNAs)、EBV编码小RNAs(EBV-encoded small RNAs,EBERs)和EBV微小RNA(EBV microRNAs,EBV miRNAs).通过与潜在靶基因相互作用,EBV非编码RNA在病毒复制与潜伏、肿瘤细胞存活、增殖、转移和免疫逃逸等方面扮演重要角色,是近年来的研究热点.本文就EBV lncRNAs,EBERs和EBV miRNAs在EBV相关肿瘤中的功能及其介导的信号通路进行综述,并对该领域存在的问题进行讨论,以期为靶向EBV非编码RNA的临床应用提供新思路.
Abstract
Epstein-Barr virus(EBV)is classified within the gamma herpesvirus subfamily and is prevalent in the human population,exhibiting a significant association with various malignancies,including nasopharyngeal carcinoma,gastric cancer,and lymphoma.Nevertheless,the molecular mechanisms that drive EBV-associated carcinogenesis remain inadequately understood.EBV non-coding RNAs include long non-coding RNAs(EBV lncRNAs),EBV-encoded small RNAs(EBERs),and EBV microRNAs(miRNAs).Epstein-Barr virus(EBV)non-coding RNAs significantly influence various biological processes,including viral replication,latency,tumor cell survival,proliferation,metastasis,and immune evasion by their interactions with potential target genes.This area of research has garnered considerable attention from the EBV research community in recent years.In this review,we provide a comprehensive summary of the functions and signaling pathways associated with EBV non-coding RNAs,while also discussing critical issues within the field.We aim to offer novel insights for the clinical application of targeting EBV non-coding RNAs.
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