EB病毒通过感染B淋巴细胞,在多种B细胞淋巴瘤的发生和发展中发挥重要作用.围绕EB病毒的研究不仅能够显著提升对B细胞淋巴瘤的临床诊断与疾病监测水平,还为阐明其致病机制以及开发精准高效的治疗策略提供关键线索.本文综述了三类常见的EB病毒相关B细胞淋巴瘤——伯基特淋巴瘤(Burkitt lymphoma)、霍奇金淋巴瘤(Hodgkin lymphoma)和弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma)的研究进展,重点总结了病毒感染在B细胞淋巴瘤发生和发展中的分子机制,并系统探讨了靶向EB病毒的治疗策略及其应用前景,为推动相关疾病的精准医学研究和临床转化提供了重要理论依据和实践指导.
Advancements in Epstein-Barr virus-associated B-cell lymphomas:molecular mechanisms and targeted therapeutic strategies
Epstein-Barr virus(EBV)plays a critical role in the initiation and progression of various types of B-cell lymphomas through its infection of B lymphocytes.Research on EBV not only significantly enhances the clinical diagnosis and disease monitoring of B-cell lymphomas but also provides key insights into its pathogenic mechanisms and the development of precise and effective therapeutic strategies.This review summarizes recent advancements in the study of three common EBV-associated B-cell lymphomas:Burkitt lymphoma(BL),Hodgkin lymphoma(HL),and diffuse large B-cell lymphoma(DLBCL).It focuses on the molecular mechanisms underlying EBV infection in the pathogenesis of B-cell lymphomas and systematically discusses EBV-targeted therapeutic strategies and their clinical potential.These findings provide valuable theoretical foundations and practical guidance for advancing precision medicine research and clinical translation in EBV-associated diseases.
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