Epidemiology,molecular characteristics,and clinical application of immunotherapy strategies for EBV-associated gastric cancer
EBV-associated gastric cancer(EBVaGC)is a type of gastric cancer related to the infection of Epstein-Barr virus(EBV),with a low incidence rate.EBVaGC tends to occur in younger patients,male predominance,and is often diagnosed as locally advanced with a good prognosis.The tumor microenvironment of EBVaGC is characterized by significant lymphocyte infiltration,contributing to a more active immune landscape.Patients with advanced EBVaGC have a higher response rate to immune checkpoint inhibitors compared to patients with ordinary gastric cancer.This article reviews the disease characteristics and the treatment progress of EBVaGC.
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