Advances in the regulation of host fat metabolism by Lactobacillus
Lipid metabolism disorder is one of the main factors causing metabolic syndrome.In animal models displaying disrupted fat metabolism or in clinical populations affected by obesity,there are substantial changes in the diversity and composition of gut microbiota,particularly within the genus Lactobacillus.As a probiotic,Lactobacillus is expected to extensively impact host fat metabolism.Therefore,this study explored the relationship between Lactobacillus and fat metabolism.It analyzed the underlying molecular mechanisms by which metabolites of Lactobacillus(such as short-chain fatty acids,bile acids,exopolysaccharides,and linoleic acid)regulate fat metabolism.Additionally,the study elaborated on the differences between the same and different Lactobacillus complexes to clarify the mechanism of lactic acid bacteria in regulating host fat metabolism.This study aims to provide perspectives and references for controlling food-borne metabolic diseases caused by lipid metabolism disorders.
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